Lead Investigator Bio

Huilin Li Laboratory
Huilin Li, Ph.D.
Chair and Professor, Department of Structural Biology

Areas of expertise: Structural biology, cryo-electron microscopy, biophysics, DNA replication, membrane protein biochemistry


Huilin Li is an internationally recognized structural biologist with more than 20 years of experience in cryo-electron microscopy (cryo-EM). His current work focuses primarily on the structural basis of DNA replication, the bacterial proteasome system and regulation and modification of the Notch receptor.

Dr. Li earned his Ph.D. in electron crystallography from the University of Science and Technology Beijing, where he trained with the late Prof. K.H. Kuo. He then completed postdoctoral research in the labs of Dr. Bing Jap and Dr. Kenneth Downing at Lawrence-Berkeley National Laboratory, where he studied membrane channels and microtubule structure by cryo-EM. From there, he joined Brookhaven National Laboratory as an associate biophysicist, rising through the ranks to attain a tenured position. In 2010, he joined Stony Brook University as a professor in the Department of Biochemistry and Cell Biology while also maintaining a summer appointment at Brookhaven. He is now a professor in Van Andel Institute’s Center for Cancer and Cell Biology.